Hexachlorobenzene exposure: widespread toxicant produces pervasive effects.

Hexachlorobenzene exposure: widespread toxicant produces pervasive effects.

Neurotrauma represents a significant public health problem, accounting for a significant proportion of the morbidity and mortality associated with all traumatic injuries. Both blunt and penetrating injuries to cervicocerebral vessels are significant and are likely more common than previously recognized. Imaging of such injuries is an important component in the evaluation of individuals presenti...

Changes in the Dose–Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant

We considered, in general form for a 22 full factorial experiment, linear approximations of the organism's dose-response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiment...

Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats.

Hexachlorobenzene (HCB) is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the reproductive and immune system. To obtain more insight into HCB-induced mechanisms of toxicity, we studied gene expression levels using DNA microarrays. For 4 weeks, Brown Norway rats were fed a diet suppleme...

Exposure to TDCPP Appears Widespread

A 150 News | Forum flame retardants exposure to tdCPP appears Widespread At a time of growing debate over the safety and usefulness of flame retardants added to consumer products, 1 new evidence is emerging about the breadth of human exposure to one of the most widely used of these compounds. Two new studies 2,3 document the presence of the flame retardant tris(1,3-dichloro-2-propyl) phosphate ...

Hepatocellular carcinoma and exposure to hexachlorobenzene: a case report.